6-Nitro-1,3-benzodioxole-5-carboxylic acid → 6-Amino-1,3-dioxaindane-5-carboxylic acid

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Reaction Steps

6-nitro-benzo[1,3]dioxole-5-carboxylic acid (19 g, 90 mmol) in 500 mL ethanol was hydrogenated at 50 psig over 5 g of 5% palladium on carbon for 2 hours. Catalyst was filtered off with Celite® and solvent was removed in vacuo to give 6-amino-benzo[1,3]dioxole-5-carboxylic acid; 4.5 g (27%) used without further purification.

Provenance & Evidence