Formamide → HCID 135679869, compound

HRID 1249743Notes

Reaction equation

HRID 1249743 reaction equation
[NH2:1][C:2]1[C:3]([C:11]([OH:13])=O)=[CH:4][C:5]2[O:9][CH2:8][O:7][C:6]=2[CH:10]=1.[CH:14]([NH2:16])=O>>[O:9]1[C:5]2=[CH:4][C:3]3[C:11](=[O:13])[NH:16][CH:14]=[N:1][C:2]=3[CH:10]=[C:6]2[O:7][CH2:8]1

Participants

3

Reactant 2

HCID 713FormamideHCID 70640686-Amino-1,3-dioxaindane-5-carboxylic acid

Product 1

HCID 135679869HCID 135679869, compoundYield 27%

Conditions

Temperature
140 °C

Procedure

A mixture of 6-amino-benzo[1,3]dioxole-5-carboxylic acid (4.3 g, 23.7 mmol) and formamide (15 mL) was heated to 140° C. for 2 hours, then to 170° C. for 2 hours. After cooling to room temperature, precipitate was collected to give 7H-[1,3]dioxolo[4,5-g]quinazolin-8-one (1.11 g, 27%).

Workup

  1. temperatureAfter cooling to room temperature
  2. customprecipitate was collected

Sources & evidence

ORD record
ord-567a47db4da340eda394e5ce63285dd8
Source dataset
uspto-grants-2002_01
Patent number
US06335344B1

Reaction notes

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