Dimethylformamide → HCID 9839231, compound

Participants

Reaction Steps

NaH (1.5 eq; 60% suspension in oil) is added to a solution of 1-methylene-2-butyryl-6-methoxy-1,2,3,4-tetrahydro-β-carboline (160 mg; 0.6 mmol) in DMF (3 ml). The mixture is stirred under an oxygen atmosphere for 6 hours. The DMF is then distilled off under reduced pressure. The crude product is washed several times with ethyl acetate. After filtration and drying, 2-butyryl-7-methoxy-3-methylene-9-oxo-1,3,4,9-tetrahydropyrrolo[3,4-b]quinoline is obtained (yield=40%).

Provenance & Evidence