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Benzyl Bromide → 3-(Benzyloxy)-2-(1-hydroxypropyl)-6-methyl-4H-pyran-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzyl Bromide | HCID 7498 | — |
| 反応物 | 3-Hydroxy-2-(1-hydroxypropyl)-6-methyl-4H-pyran-4-one | HCID 10655077 | — |
| 反応物 | 2-hydroxymethyl-3-benzyloxy-6-methyl-pyran-4(1H)-one | HCID 11139409 | — |
| 生成物 | 3-(Benzyloxy)-2-(1-hydroxypropyl)-6-methyl-4H-pyran-4-one | HCID 18678826 | — |
反応手順
The title compound was prepared by the method outlined for 2-hydroxymethyl-3-benzyloxy-6-methyl-pyran-4(1H)-one, using 7.36 g (40 mmol, 1 eq.) of 2-(1-hydroxypropyl)-3-hydroxy-6methyl-pyran-4(1H)-one and 7.5 g benzyl bromide (44 mmol, 1.1 eq.) to yield the pure product 8.9 g (81.2%) after recrystallisation from CH2Cl2/Pet. ether 40/60, as a white crystalline solid. m.p. 88-89° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06335353B1 |
| 出典データセット | uspto-grants-2002_01 |
| ORD ID | ord-24abb9bfae4d44d8b7299e350fd808e2 |
| 出典メモ | uspto-grants-2002_01 |