HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethyl-2-methoxymethyl-3-benzyloxy-pyridin-4(1H)-one → 1-Ethyl-2-(1-methoxyethyl)-3-benzyloxy-pyridin-4(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethyl-2-methoxymethyl-3-benzyloxy-pyridin-4(1H)-one | HCID 18678807 | — |
| Reactant | 2-(1-Methoxyethyl)-3-benzyloxy-pyran-4(1H)-one | HCID 18678816 | — |
| Product | 1-Ethyl-2-(1-methoxyethyl)-3-benzyloxy-pyridin-4(1H)-one | HCID 18678822 | 29.6% |
Reaction Steps
In an analogous procedure in the preparation of 1-ethyl-2-methoxymethyl-3-benzyloxy-pyridin-4(1H)-one using 2-(1-methoxyethyl)-3-benzyloxy-pyran-4(1H)-one 3.12 g (12 mmol, 1 eq.) yielded the title compound (1.03 g, 29.6%) after purification by column chromatography on silica gel (eluant: 15% CH3OH/85% CHCl3) as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06335353B1 |
| Source dataset | uspto-grants-2002_01 |
| ORD ID | ord-691adffbb5114065b977e8ac6b0ed63a |
| Source note | uspto-grants-2002_01 |