反应详情

To 4-aminobenzophenone (1.97 g) dissolved in pyridine (50 mL), phenyl chlorocarbonate (1.38 g) was added at 0° C. and the mixture was stirred at room temperature for 1 hour. The reaction mixture was poured into water and extracted with ethyl acetate. The organic layer was dried over anhydrous Na2SO4 and evaporated. The residue was purified by column chromatography on silica gel (hexane/ethyl acetate=4/1 to 1/2) to give the subject compound (3.1 g).

1. extractionextracted with ethyl acetate
2. dry with materialThe organic layer was dried over anhydrous Na2SO4
3. customevaporated
4. customThe residue was purified by column chromatography on silica gel (hexane/ethyl acetate=4/1 to 1/2)