反应详情

2-amino-5-(3-methoxyphenyl)pyrazine (566 mg) was dissolved in methylene chloride (10 mL). To this mixture was added under ice-cooling boron tribromide (530 μL) and the whole was stirred at room temperature for 14 hours. To the reaction mixture was added 1N aqueous sodium hydroxide. The whole was extracted with ethylacetate (30 mL×2). The organic layer was washed with saturated saline solution and then dried over anhydrous Na2SO4. The concentration of the solvent provides the subject compound (94 mg) as a yellow solid.

1. additionTo this mixture was added under ice-
2. extractionThe whole was extracted with ethylacetate (30 mL×2)
3. washThe organic layer was washed with saturated saline solution
4. dry with materialdried over anhydrous Na2SO4