Triethylamine → HCID 131723066, compound

Participants

Reaction Steps

Triethylamine (4.9 mL, 33 mmol) was added to the solution of 1-(N-t-butoxycarbonyl-2(S)-aminobutyryl)-5-benzyloxyindoline-2(S)-carboxylic acid (2.6 g, 5.72 mmol) and 2,2,2-trifluoroethylamine hydrochloride (1.55 g, 11.4 mmol) in dried dichloromethane (50 mL) at 0° C. under nitrogen, followed by bis(2-oxo-3-oxazolidinyl)phosphinic chloride (2.902 g, 11.4 mmol). The temperature was allowed to rise to room temperature and the mixture was stirred at room temperature for twenty-four hours, then filtered. The filtrate was concentrated under vacuum to give a brown solid which was purified by column chromatography (silica gel, 8:2 diethyl ether: petroleum spirit) to provide a white solid as the desired product.

Provenance & Evidence