2-Chlorobenzaldehyde → HCID 53962035, compound

Participants

Reaction Conditions

Reaction Steps

Sodium pieces(3.678 g, 160 mmol) were added in portions to methanol (200 ml) over a 30 minute period. The resulting solution was cooled in a dry ice/acetone bath to −18° C. and then over one hour a mixture of 2-chlorobenzaldehyde (4.832 g, 40 mmol) and methyl azidoacetate (160 mmol) was added at a rate that maintained the temperature below −15° C. After three hours, the solution was stored at 5° C. for two days to give crystalline material which was collected by filtration and washed with cold hexane to give pure product as a yellow crystals.

Provenance & Evidence