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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1249939Generated: October 29, 2026

ethyl 4,5-dichloro-1H-indole-2-carboxylate → 4,5-Dichloroindoline-2-(r/s)-carboxylic acid methyl ester

https://huagongshe.com/reaction/1249939

Reaction equation

Participants

RoleNameHCIDCharge
Reactantethyl 4,5-dichloro-1H-indole-2-carboxylateHCID 4714971—
ReactantMagnesiumHCID 5462224—
Product4,5-Dichloroindoline-2-(r/s)-carboxylic acid methyl esterHCID 76457839—

Reaction Steps

This compound was prepared from ethyl 4, 5-dichloroindole-2-carboxylate as described in Example 1, using 6-7 eq. of magnesium turnings instead of 2-3 eq. of magnesium turnings.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06335360B1
Source datasetuspto-grants-2002_01
ORD IDord-e9e5d2eb4324466ea3165a35e847aa20
Source noteuspto-grants-2002_01