Ethanamine, 2,2,2-trifluoro- → HCID 131723066, compound

HRID 1249942Notes

Reaction equation

HRID 1249942 reaction equation
[C:1]([O:5][C:6]([NH:8][C@@H:9]([CH2:32][CH3:33])[C:10]([N:12]1[C:20]2[C:15](=[CH:16][C:17]([O:21][CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[CH:18][CH:19]=2)[CH2:14][CH:13]1[C:29](O)=[O:30])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].[F:34][C:35]([F:39])([F:38])[CH2:36][NH2:37]>>[F:34][C:35]([F:39])([F:38])[CH2:36][NH:37][C:29]([CH:13]1[CH2:14][C:15]2[C:20](=[CH:19][CH:18]=[C:17]([O:21][CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH:16]=2)[N:12]1[C:10](=[O:11])[C@@H:9]([NH:8][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[CH2:32][CH3:33])=[O:30]

Participants

3

Reactant 2

HCID 9773Ethanamine, 2,2,2-trifluoro-HCID 131723064HCID 131723064, compound

Product 1

HCID 131723066HCID 131723066, compound

Procedure

This compound was prepared from 1-(N-t-butoxycarbonyl-2(S)-aminobutyryl)-5-benzyloxyindoline-2-(R/S)-carboxylic acid and trifluoroethylamine as described in Example 15.

Sources & evidence

ORD record
ord-8b1af6efc23043958efb75a27c44053c
Source dataset
uspto-grants-2002_01
Patent number
US06335360B1

Reaction notes

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