1,3-Benzodioxole-4-carboxaldehyde → HCID 53799897, compound

Participants

Reaction Steps

A solution of 2,3-methylenedioxy benzaldehyde (15.76 g, 104 mmol) and methylazidoacetate (48.38 g, 419 mmol) in methanol was cooled to −15° C. using an ice/acetone bath. The resulting solution was then treated over one hour with sodium methoxide (96 ml) at a rate that maintained the temperature below −10° C. After 3 hours, the solution was stored at 5° C. for two days to give crystalline material which was filtered off and washed with hexane.

Provenance & Evidence