HCID 131723066, compound → HCID 131723067, compound

Participants

Reaction Steps

1-[N-t-butoxycarbonyl-2(S)-aminobutyryl]-5-benzyloxyindoline-2(R/S)-carboxylic acid (2,2,2-trifluoroethyl)amide (1.27 g, 5.39 mmol) in ethyl acetate (28 ml) was hydrogenated under an atmosphere of hydrogen in the prescence of palladium on activated carbon at room temperature for 24 hours. The catalyst was filtered through celite with ethyl acetate washing. The filtrate was concentrated and directly chromatographed on silica gel using 2:3 petroleum spirit:ethyl acetate as eluent.

Provenance & Evidence