HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-Hydroxy-3-Methoxyphenyl)Prop-2-Enoic Acid → Methyl 4-hydroxy-3-methoxy-cinnamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-Hydroxy-3-Methoxyphenyl)Prop-2-Enoic Acid | HCID 709 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Product | Methyl 4-hydroxy-3-methoxy-cinnamate | HCID 16830 | — |
Reaction Steps
The preparation was effected analogously to Example 1 from 25 g (0.129 mol) of 4-hydroxy-3-methoxy-cinnamic acid and 180 ml of methanol with concentrated sulphuric acid as the catalyst. For purification, it was chromatographed on silica gel with dichloromethane/diethyl ether (19:1). This gave 21.78 g of methyl 4-hydroxy-3-methoxy-cinnamate as a pale yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06335409B1 |
| Source dataset | uspto-grants-2002_01 |
| ORD ID | ord-ecfe1b6085494f07b93e938c2ed914c2 |
| Source note | uspto-grants-2002_01 |