関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Fluorobenzonitrile | HCID 14517 | — |
| 反応物 | 4-Phenylpiperidine | HCID 69873 | — |
| 溶媒 | N-Methyl-2-piperidone | HCID 13603 | — |
| 生成物 | 4-Phenyl-1-(4-cyanophenyl)piperidine | HCID 18001056 | 48.7% |
反応手順
4-Phenylpiperidine (0. 5 g), p-fluorobenzonitrile (0.37 g) and potassium carbonate (0.78 g) are dissolved in N-methylpiperidone (5 ml), and the mixture is stirred at 120° C. for five hours. To the reaction solution is added ethyl acetate (50 ml), and the mixture is washed with water, dried over magnesium sulfate, filtered, and concentrated under reduced pressure. To the resulting residue is added methanol, and the insoluble crystals are collected by filtration, dried under reduced pressure to give 4-phenyl-1-(4-cyanophenyl)piperidine (0.39 g) as white needles.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06335327B1 |
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| 出典データセット | uspto-grants-2002_01 |
|---|
| ORD ID | ord-409f65a68e0e4f41bbdabf5f34dcaecd |
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| 出典メモ | uspto-grants-2002_01 |
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