Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Maleic Acid | HCID 444266 | — |
| Reactant | Enalapril | HCID 5388962 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Enalapril Maleate | HCID 5388961 | — |
Reaction Steps
N-(1(S)-Ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-proline and acetonitrile are mixed and to this mixture is added maleic acid with heating at 70° C. and the mixture is gradually cooled to obtain N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-proline maleate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06335453B1 |
|---|
| Source dataset | uspto-grants-2002_01 |
|---|
| ORD ID | ord-c790ff249df141f3828b6de8ba83ad5b |
|---|
| Source note | uspto-grants-2002_01 |
|---|
