Sulfuric Acid → HCID 18400126, compound

Participants

Reaction Steps

2.1 g of 4′-(2-butyl-5-cyano-4-methoxyimidazol-1-ylmethyl)biphenyl-2-sulfonic acid acetylamide are suspended in 40 ml of a 20% aqueous H2SO4 solution and the mixture is refluxed for 3 h. The reaction mixture is added dropwise to 400 ml of a 2/3 M solution of KH2PO4 in water and extracted 3 times using 300 ml of EA each time. The extract is dried over Na2SO4 and the solvent is removed in vacuo. Chromatography on silica gel using MTB yields 1.6 g of a colorless oil.

Provenance & Evidence