Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Pyridinium chloride | HCID 10176127 | — |
| Reactant | HCID 11021491 | HCID 11021491 | — |
| Product | HCID 23500200 | HCID 23500200 | 58% |
Reaction Steps
3-methoxy-2-phenylbenzoic acid ethyl ester (0.53 g) and pyridine hydrochloride (6 g) were combined under nitrogen, then heated to 180° C. for 1 hour. The melt was poured into dilute aqueous hydrochloric acid and extracted with ethyl acetate. Purification by silica gel chromatography, eluting with hexane/acetone (2:1) with 0.5% acetic acid, gave 3-hydroxy-2-phenylbenzoic acid as a white solid (0.25 g, 58%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06335459B1 |
|---|
| Source dataset | uspto-grants-2002_01 |
|---|
| ORD ID | ord-90a05877584449199a38e0fe1102b706 |
|---|
| Source note | uspto-grants-2002_01 |
|---|
