Lithium Hydroxide → HCID 9822433, compound

Participants

Reaction Steps

1.0M Lithium hydroxide (1.46 mL, 1.46 mmol) was added to a solution of trans-[3-(3-diphenylcarbamoyloxypropenyl)phenoxy}acetic acid tert-butyl ester (0.56 g, 1.22 mmol) in methanol (2 mL), tetrahydrofuran (2 mL) at room temperature under a nitrogen atmosphere. The mixture was stirred at room temperature for 3 hours. The solvent was evaporated, water was added followed by 2N hydrochloric acid to pH 1-2, and the product was extracted with ethyl acetate. The extract was washed with water, brine, dried over magnesium sulfate, and concentrated to dryness. Recrystallization in diethyl ether gave trans-[3-(3-diphenylcarbamoyloxypropenyl)phenoxy}acetic acid as a white crystalline solid (0.38 g, 78%), m.p. 112.4-113.7° C.

Provenance & Evidence