Pyridine → HCID 10352102, compound

Participants

Reaction Steps

The purified cyanohydrin was dissolved in 5 ml of dry diethyl ether, and the solution was treated with 2 mol equivalents of acetic anhydride and 2 mol equivalents of pyridine and stirred at room temperature for 8 hours. It was then extracted with 10 ml each of 5% H2SO4, distilled water and saturated NaHCO3 solution, dried over anhydrous sodium sulfate and the solvent was removed under reduced pressure. After purification by column chromatography, 182 mg of (S)-2-acetoxyheptanenitrile were obtained (98% isolated yield). e.e.=96% (determined by gas chromatography)

Provenance & Evidence