Azobisisobutyronitrile → HCID 53938046, compound

Participants

Reaction Steps

A mixture of 2.2 g of methyl 2-(2-methylphenoxy)-3-methoxyacrylate, 1.78 g of N-bromosuccinimide, and a catalytic amount of azobisisobutyronitrile was heated at reflux in carbon tetrachloride for 4 hours. The solid was filtered, and the solvent evaporated to give crude methyl 2-(2-bromomethylphenoxy)-3-methoxyacrylate. A mixture of this crude material, 2.0 g of N-benzyloxy propionamide, and 3.9 g of caesium carbonate was heated at reflux in acetonitrile for 20 hours. The solid was filtered, the solvent evaporated, and the residue purified by silica gel chromatography to give methyl 2-{2-[(1-benzyloxyiminopropyl)oxymethyl]phenoxy}-3-methoxyacrylate (isomer Z) (0.75 g).

Provenance & Evidence