Hydrogen Bromide → 3-Chloro-2-(4-chlorobenzyl)-5-trifluoromethylpyridine

Participants

Reaction Conditions

Reaction Steps

4.3 g of 3-chloro-2-[1-(4-chlorophenyl)-1-cyanomethyl]-5-trifluoromethylpyridine (prepared by the method of Example 1) were heated under reflux in 50 ml of 47% strength aqueous hydrogen bromide solution for 3 hours and then stirred for another 68 hours at 23° C. The reaction mixture was subsequently poured into 500 ml of ice water. The mixture was stirred for a further 30 minutes and the solid that had formed was separated off, washed with water and then dried. Yield: 3.0 g (75%) of colorless crystals; mp.: 54-56° C.).

Provenance & Evidence