反应详情

A solution of 0.3 g of potassium hydroxide in 1 ml water and 0.6 ml of carbon disulfide were successively added to a solution of 1.1 g (7.2 mmol) of 4-methyl-1,2,3-thiadiazole-5-carbohydrazide in 15 ml ethanol. The mixture was stirred for 6.5 hours with heating under reflux. After the reaction was completed, the solvent was distilled off under reduced pressure, water was added to the residue, acetic acid was added for the sake of acidification, and the deposited crystalline product was collected by filtration. Thus, 0.82 g of the objective compound was obtained.

1. temperaturewith heating
2. temperatureunder reflux
3. distillationthe solvent was distilled off under reduced pressure, water
4. additionwas added to the residue, acetic acid
5. additionwas added for the sake of acidification
6. filtrationthe deposited crystalline product was collected by filtration