Water → HCID 86757711, compound

Participants

Reaction Conditions

Reaction Steps

(4aR, 12aR)-4a-(3-benzyloxyphenyl)-2-vinyloxycarbonyl-1,2,3,4,4a,5,12,12a-octahydroquinolino[2, 3-g]isoquinoline (181 mg, 0.369 mmol) was dissolved in a 10% hydrogen chloride methanol solution (6 ml), and the resultant solution was heated under reflux for 1 hour. After the solution was cooled to 0°C., an aqueous saturated sodiumbicarbonate solution (30 ml) and water (150 ml) were added to the solution, followed by extraction with chloroform (200 ml, 2 times). The organic layers were dried, and then concentrated to obtain the target compound (155 mg). The thus-obtained compound was supplied to next reaction without purification.

Provenance & Evidence