Potassium Carbonate → HCID 10166710, compound

Participants

Reaction Steps

A solution of 2-(4-chloro-phenoxymethyl)-8-methoxy-3-(3-piperidin-4-yl-propyl)-3H-quinazolin-4-one (150 mg, 0.31 mmol), N-(3-chloropropyl)-piperidine hydrochloride (222 mg, 0.63 mmol), K2CO3 (87 mg, 0.63 mmol), Kl (105 mg, 0.63 mmol) was heated at 80° C. in THF/H2O (3:1 mixture, 30 mL) for 17 h. After cooling to room temperature, the reaction mixture was diluted with EtOAc. The organic solution was separated and was washed with sat'd aq NaHCO3, sat'd aq NaCl, dried and concentrated. The crude residue was chromatographed on SiO2-gel using EtOAc/NEt3 (10:1) to give the desired product as an oil. API-MS: 567.2 (M+1). 1H NMR (300 MHz, d4-MeOH): d 7.75 (d, 1 H), 7.5 (t,1 H), 7.38 (d, 1 H), 7.3 (d, 2 H), 7.1 (d, 2 H), 5.25 (s, 2 H), 4.1 (m, 2 H), 4.0 (s, 3 H), 2.9 (m), 2.4-2.1 (m), 1.9-1.1 (m).

Provenance & Evidence