Water → HCID 131723088, compound

Participants

Reaction Steps

To a solution of (4E)-N-methyl-5-(3-fluorophenyl)-4-penten-2-amine (228.5 mg, 1.182 mmol) in absolute ethanol (3.6 mL) was added galactaric acid (124.2 mg, 0.591 mmol). Water (0.7 mL) was added drop-wise while gently warming the solution. The solution was filtered through glass wool to remove a few insoluble particles, washing the filter plug with ethanol-water (4:1, v/v) (1 mL). The filtrate was diluted with ethanol (5.6 mL), cooled to ambient temperature, and further cooled at 5° C. for 18 h. The solids were filtered, washed with cold ethanol and vacuum dried at 40° C. to give 246 mg (69.6%) of a fluffy white, crystalline powder, mp 164-166° C.

Provenance & Evidence