Hydrogen Bromide → HCID 10198149, compound

Participants

Reaction Conditions

Reaction Steps

A solution of (4E)-N-methyl-N-(tert-butoxycarbonyl)-5-(3-amino-4-methylphenyl)-4-penten-2-amine (1.50 g, 4.93 mmol) and aqueous hydrobromic acid (50%, 25 mL) was stirred at 0° C. to ambient temperature for ˜16 h. The reaction mixture was extracted with chloroform (40 mL). The aqueous layer was cooled to 0° C. and basified with aqueous sodium hydroxide solution to pH 8-9 and extracted with chloroform (3×50 mL). The combined extracts were dried over sodium sulfate, filtered and concentrated on a rotary evaporator to yield 0.938 g (93.3%) of a brown oil.

Provenance & Evidence