Water → HCID 131723091, compound

Participants

Reaction Steps

To a hot solution of (4E)-N-methyl-5-(3-amino-4-methylphenyl)-4-penten-2-amine (900 mg, 4.41 mmol) in ethanol (40 mL) was added galactaric acid (463 mg, 2.20 mmol). The mixture was heated to reflux and water (0.5 mL) was added drop-wise. The clear solution was filtered to remove some insoluble particles. The filtrate was concentrated to 25 mL and cooled to ambient temperature. The precipitate was filtered, washed with anhydrous ether and dried in a vacuum oven at 45° C. for ˜16 h. The yield was 1.16 g (85.6%) of a white powder, mp 186-189° C.

Provenance & Evidence