Hydrogen Bromide → HCID 10198785, compound

Participants

Reaction Conditions

Reaction Steps

A solution of (4E)-N-methyl-N-(tert-butoxycarbonyl)-5-(3-acetamido-4-methylphenyl)-4-penten-2-amine (0.90 g, 2.60 mmol) and aqueous hydrobromic acid (50%, 25 mL) was stirred at 0° C. to ambient temperature for ˜16 h. The reaction mixture was extracted with chloroform (40 mL). The aqueous layer was cooled to 0° C., basified with aqueous sodium hydroxide solution to pH 8-9, and extracted with chloroform (4×50 mL). The combined extracts were dried over sodium sulfate, filtered and concentrated on a rotary evaporator to yield 0.639 g (94.6%) of a colorless oil.

Provenance & Evidence