反应详情

温度

150 °C

A mixture of 1.5 g (7.0 mmol) of 4-(bromomethyl)-3-fluorobenzonitrile [ref. J.Med.Chem., 40, 2064 (1997)] and 1.4 g (8.4 mmol) of triethyl phosphite was heated at 150° C. for 2 hours. At the end of this time, the reaction mixture was concentrated under reduced pressure. Volatile materials in the residue thus obtained were removed by heating said residue at 100° C. in vacuo for 1 hour to afford 1.97 g (quantitative yield) of the title compound as an oil which solidified in the freezer. This oily product was used in the next step without further purification.

1. concentrationAt the end of this time, the reaction mixture was concentrated under reduced pressure
2. customVolatile materials in the residue thus obtained
3. customwere removed
4. temperatureby heating
5. customat 100° C.
6. customfor 1 hour