Methanol → HCID 131723093, compound

Participants

Reaction Steps

This compound was prepared from (R)-5-benzyloxy-1-(3-thiocarbamoyl-benzyl)-1H-indole-2-carboxylic acid (1-phenyl-ethyl)-amide, methyl iodide, and ammonium acetate as described in example 1/5, but for the methylation acetone was used as solvent and in the last step methanol and acetone were used as solvents. The crude material was purified by flash chromatography on silica gel with dichloromethane/methanol/acetic acid 9:0.25:0.5 to give the desired product in 28% yield. M.p. 72° C. (dec.). MS: 503.3 (M+H+).

Provenance & Evidence