Ammonia → [4-({[1-(3-Amidino-benzyl)-5-fluoro-1h-indole-2-carbonyl]-amino}-methyl)-phenyl]-trimethyl-ammonium acetate acetic acid salt

Participants

Role	Name	HCID	Charge
Reactant	Ammonia	HCID 222	—
Reactant	Hydrochloric Acid	HCID 313	—
Reactant	[4-({[1-(3-cyano-benzyl)-5-fluoro-1H-indole-2-carbonyl]-amino}-methyl)-phenyl]-trimethyl-ammonium iodide	HCID 18327608	—
Reactant	Trifluoroacetic acid acetate	HCID 23437676	—
Product	[4-({[1-(3-Amidino-benzyl)-5-fluoro-1h-indole-2-carbonyl]-amino}-methyl)-phenyl]-trimethyl-ammonium acetate acetic acid salt	HCID 69779712	—

Reaction Steps

This compound was prepared from [4-({[1-(3-cyano-benzyl)-5-fluoro-1H-indole-2-carbonyl]-amino}-methyl)-phenyl]-trimethyl-ammonium iodide, hydrogen chloride, and liquid ammonia analogously to example 19/3. Instead of trifluoroacetic acid acetic acid was used for chromatography. Yield: 74%. M.p. 172° C. (dec.). MS: 458.2 (M+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06337344B1
Source dataset	uspto-grants-2002_01
ORD ID	ord-f27051570b5c493a85a6260e159f7822
Source note	uspto-grants-2002_01