Water ethanol trifluoroacetic acid → [4-({[1-(3-Amidino-benzyl)-5-fluoro-1H-indole-2-carbonyl]-amino}-methyl)-phenyl]-trimethyl-ammonium trifluoroacetate trifluoroacetic acid salt

Participants

Role	Name	HCID	Charge
Reactant	Water ethanol trifluoroacetic acid	HCID 18377865	—
Reactant	[4-({[1-(3-Amidino-benzyl)-5-fluoro-1h-indole-2-carbonyl]-amino}-methyl)-phenyl]-trimethyl-ammonium acetate acetic acid salt	HCID 69779712	—
Product	[4-({[1-(3-Amidino-benzyl)-5-fluoro-1H-indole-2-carbonyl]-amino}-methyl)-phenyl]-trimethyl-ammonium trifluoroacetate trifluoroacetic acid salt	HCID 86757719	100%

Reaction Steps

[4-({[1-(3-Amidino-benzyl)-5-fluoro-1H-indole-2-carbonyl]-amino}-methyl)-phenyl]-trimethyl-ammonium acetate acetic acid salt (32/2) was dissolved in water/ethanol/trifluoroacetic acid 1:1:0.1. The product was separated by flash chromatography on RP18 material with water/ethanol/trifluoroacetic acid 1:1:0.1 to give the trifluoroacetic acid salt in 100% yield. M.p.120-124° C. MS: 458.2 (M+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06337344B1
Source dataset	uspto-grants-2002_01
ORD ID	ord-a28cd31aafa94a24b75f7ce4e5251f9a
Source note	uspto-grants-2002_01