Trifluoroacetic acid → HCID 86757724, compound

Participants

Reaction Steps

The starting material, [4-({[5-benzyloxy-1-(3-amidino-benzyl)-1H-indole-2-carbonyl]-amino}-methyl)-phenyl]-trimethyl-ammonium trifluoroacetate trifluoroacetic acid salt (example 56), was dissolved in ethanol, 2 equivalents of trifluoroacetic acid and Pd/C (10%) were added and the mixture was hydrogenated. The reaction mixture was concentrated and purified by flash-chromatography on silica gel with dichloromethane/methanol/trifluoroacetic acid 9:1:0.1. The product was concentrated and lyophilized to give 53% of the desired product. M.p. 78° C. (dec.). MS: 456.4 (M+).

Provenance & Evidence