Ammonia → HCID 18327562, compound

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This compound was prepared from allyl-[4-({[1-(3-cyano-benzyl)-5-fluoro-1H-indole-2-carbonyl]-amino}-methyl)-phenyl]-dimethyl-ammonium bromide (222 mg, 0.406 mmol), ethanol (12 ml), hydrogen chloride, and liquid ammonia analogously to example 19/3. The crude product was purified by chromatography on silica gel with dichloromethane/methanol/acetic acid 3:2:0.05 to 1:4:0.05. Lyophilization gave 131 mg of the desired product (56%). M.p. 133° C. (dec.). MS: 484.3 (M+).

Provenance & Evidence