Acetic Acid → HCID 18327665, compound

Participants

Reaction Steps

This compound was prepared from 4-benzyloxy-1-(3-thiocarbamoyl-benzyl)-1H-indole-2-carboxylic acid 4-(dimethylamino)-benzylamide (342 mg, 0.62 mmol), acetone (15 ml), methyl iodide (0.98 ml, 15 mmol), acetic acid (0.4 m, 0.7 mmol), ammonium acetate (809 mg, 10 mmol), and methanol (7 ml) as described in example 1/5 but the solvent for the methylation was pure acetone. The crude material was purified by flash chromatography on RP18 material with ethanol/water/acetic acid 1:1:0.1 to give 374 mg of the desired compound (80 %). M.p. 158° C. (dec.). MS: 546.2 (M+).

Provenance & Evidence