Ammonia → HCID 18327546, compound

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Reaction Steps

This compound was prepared from [4-({[4-bromo-1-(3-cyano-benzyl)-1H-indole-2-carbonyl]-amino}-methyl)-phenyl]-trimethyl-ammonium iodide (200 mg, 0.32 mmol), ethanol (13 ml), hydrogen chloride, and liquid ammonia analogously to example 19/3. Purification by reversed phase chromatography on RP18 material with water/ethanol/trifluoroacetic acid 1:1:0.1 gave 249 mg of the desired product as trifluoroacetic acid salt. This compound was converted into the acetic acid salt by ion exchanger chromatography analogously to example 64. Yield: 150 mg (74%). M.p. 145° C. (dec.). MS: 518.2 (M+; 79Br).

Provenance & Evidence