Diisopropylethylamine → HCID 70087585, compound

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Reaction Steps

This compound was prepared from 1-(3-pyridyl-methyl)-1H-indole-2-carboxylic acid (200 mg, 0.79 mmol), diphenylphosphoryl azide (222.7 μl, 1.03 mmol), N,N-diisopropylethylamine (364 μl), and 4-dimethylamino-benzylamine dihydrochloride (632.3 mg, 2.84 mmol) in N,N-dimethylformamide (10 ml) as described in example 3/1. The purification by flash chromatography on silica gel was done with toluene/ethyl acetate first 6:1, then going to pure ethyl acetate in two steps: 228.7 mg (76%) of the desired product were obtained. M.p. 108-110° C. MS: 385.3 (M+H+).

Provenance & Evidence