HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Trifluoroacetic acid → 1-(carboxy-methyl)-1H-indole-2-carboxylic ethyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Trifluoroacetic acid | HCID 6422 | — |
| Edukt | 1-(tert-Butyloxycarbonyl-methyl)-1H-indole-2-carboxylic acid ethyl ester | HCID 54347069 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | 1-(carboxy-methyl)-1H-indole-2-carboxylic ethyl ester | HCID 18327607 | — |
Reaktionsschritte
1-(tert-Butyloxycarbonyl-methyl)-1H-indole-2-carboxylic acid ethyl ester was treated with trifluoroacetic acid in dichloromethane to give 1-(carboxy-methyl)-1H-indole-2-carboxylic ethyl ester. Reaction of the latter intermediate with oxalyl chloride in dichloromethane gave the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06337344B1 |
| Quelldatensatz | uspto-grants-2002_01 |
| ORD ID | ord-6d28ae071f604518abfe0afd006dd9c8 |
| Quellennotiz | uspto-grants-2002_01 |