Sodium Hydroxide → HCID 18326251, compound

HRID 1250439Notes

Reaction equation

HRID 1250439 reaction equation
[Cl:1][C:2]1[C:7]([C:8]([O:10]CC)=[O:9])=[CH:6][C:5]([C:13]2[C:17]([CH3:18])=[C:16]([C:19]#[N:20])[N:15]([CH3:21])[N:14]=2)=[C:4]([F:22])[CH:3]=1.[OH-].[Na+]>O1CCOCC1>[Cl:1][C:2]1[C:7]([C:8]([OH:10])=[O:9])=[CH:6][C:5]([C:13]2[C:17]([CH3:18])=[C:16]([C:19]#[N:20])[N:15]([CH3:21])[N:14]=2)=[C:4]([F:22])[CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18326242HCID 18326242, compound

Product 1

HCID 18326251HCID 18326251, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

3.1 g of 3-(4-chloro-2-fluoro-5-carbethoxyphenyl)-4-methyl-5-cyano-1-methyl-[1H]-pyrazole (Example H13) are dissolved in 22 ml of dioxane, and 10 ml of 2N aqueous sodium hydroxide solution are added dropwise at 22° C. The mixture is stirred until the reaction is complete, the solvent is evaporated, the resulting residue is dissolved in water and the solution is brought to pH 1using hydrochloric acid. The precipitate formed is filtered off and dried. This gives the desired product in a yield of 2.63 g (89.8% of theory).

Workup

  1. customthe solvent is evaporated
  2. dissolutionthe resulting residue is dissolved in water
  3. customThe precipitate formed
  4. filtrationis filtered off
  5. customdried

Sources & evidence

ORD record
ord-6b603f1176a54d378053503ac41a7656
Source dataset
uspto-grants-2002_01
Patent number
US06339046B1

Reaction notes

Loading…