HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 1-(4-Amino-2-methylquinolin-3-yl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-(1-Methyl-3-oxobut-1-enylamino)benzonitrile | HCID 672298 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Catalyst | Cuprous chloride | HCID 62652 | — |
| Product | 1-(4-Amino-2-methylquinolin-3-yl)ethanone | HCID 672297 | — |
Reaction Steps
1-(4-Amino-2-methylquinolin-3-yl)ethanone was prepared by a known process, starting from 2-(1-methyl-3-oxobut-1-enylamino)benzonitrile, by cyclization with CuCl and K2CO3 (J. Med. Chem., 31:1278 (1988)) or by a NaOMe-promoted process (Eur. Pat. Appl., C07D 215/42); yielding a yellow solid; MS(Cl): M++H=201.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06339077B1 |
| Source dataset | uspto-grants-2002_01 |
| ORD ID | ord-f285e002db674a9fadb6bca9f04e8fb4 |
| Source note | uspto-grants-2002_01 |