HCID 12019295, compound → HCID 12019296, compound

HRID 1250449Notes

Reaction equation

HRID 1250449 reaction equation
[Br:1][C:2]1[CH:27]=[CH:26][C:5]([CH2:6][NH:7][C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=[C:10]([CH3:18])[C:9]=2[C:19]([O:21]CCCC)=[O:20])=[CH:4][CH:3]=1.[CH:28](O)([CH3:30])[CH3:29].C1COCC1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][NH:7][C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=[C:10]([CH3:18])[C:9]=2[C:19]([O:21][CH:28]([CH3:30])[CH3:29])=[O:20])=[CH:26][CH:27]=1

Participants

3

Reactant 2

HCID 12019295HCID 12019295, compoundHCID 22597222Tetrahydrofuran 2-propanol

Product 1

HCID 12019296HCID 12019296, compound

Procedure

Isopropyl 4-(4-bromobenzylamino)-2-methylquinoline-3-carboxylate was prepared in analogy to n-butyl 4-(4-bromobenzylamino)-2-methylquinoline-3-carboxylate (see Example 6) by transesterification of the corresponding methyl ester in an isopropanol/THF mixture, resulting in the title compound as a colorless oil. MS(ES+): 413/415.

Sources & evidence

ORD record
ord-1342ad52c4444bffb7f765dfe57e0b77
Source dataset
uspto-grants-2002_01
Patent number
US06339077B1

Reaction notes

Loading…