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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1250452Generated: November 1, 2026

Tin tetrachloride → 1-(4-Amino-2-methylquinolin-3-yl)ethanone

https://huagongshe.com/reaction/1250452

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTin tetrachlorideHCID 24287—
ReactantAcetylacetoneHCID 31261—
Reactant2-AminobenzonitrileHCID 72913—
Product1-(4-Amino-2-methylquinolin-3-yl)ethanoneHCID 672297—

Reaction Steps

1-(4-Amino-2-methylquinolin-3-yl)ethanone was prepared analogously to Intermediate 2a, Example 6, by tin tetrachloride-promoted reaction of 2-aminobenzonitrile and acetyl acetone in a manner known from the literature (Tetrahedron 51:12277 (1995)).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06339077B1
Source datasetuspto-grants-2002_01
ORD IDord-021fc2a1c9a946dcaba3251d60e9b209
Source noteuspto-grants-2002_01