3-Bromobenzyl bromide → 1-(4-(3-Bromobenzylamino)-2-methylquinolin-3-yl)ethanone

HRID 1250453Notes

Reaction equation

HRID 1250453 reaction equation
BrC1C=CC([CH2:6][NH:7][C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=[C:10]([CH3:18])[C:9]=2[C:19](=[O:21])[CH3:20])=CC=1.NC1C2C(=CC=CC=2)N=C(C)C=1C(=O)C.[Br:39][C:40]1[CH:41]=[C:42]([CH:45]=[CH:46][CH:47]=1)CBr>>[Br:39][C:40]1[CH:47]=[C:46]([CH:45]=[CH:42][CH:41]=1)[CH2:6][NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=[C:10]([CH3:18])[C:9]=1[C:19](=[O:21])[CH3:20]

Participants

4

Reactant 3

HCID 699793-Bromobenzyl bromideHCID 6722971-(4-Amino-2-methylquinolin-3-yl)ethanoneHCID 114628041-(4-(4-Bromobenzylamino)-2-methylquinolin-3-yl)ethanone2×

Product 1

HCID 120193031-(4-(3-Bromobenzylamino)-2-methylquinolin-3-yl)ethanone

Procedure

1-(4-(3-Bromobenzylamino)-2-methylquinolin-3-yl)ethanone was synthesized by the same process as described for 1-(4-(4-bromo-benzylamino)-2-methylquinolin-3-yl)ethanone (Example 1, Intermediate 2c) starting from 1-(4-amino-2-methylquinolin-3-yl)ethanone and 3-bromobenzyl bromide. Melting point: 109° C.; MS(ES+): 369/371.

Sources & evidence

ORD record
ord-048dfb7d81474c98ae8415598b8a5c87
Source dataset
uspto-grants-2002_01
Patent number
US06339077B1

Reaction notes

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