(R)-3-Pyrrolidinol → HCID 69686397, compound

HRID 1250467Notes

Reaction equation

HRID 1250467 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]([N:12]2[CH2:21][CH2:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[OH:22][C@@H:23]1[CH2:27][CH2:26][NH:25][CH2:24]1>CO>[ClH:1].[CH2:13]1[C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:20][CH2:21][N:12]1[C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=[C:2]([N:25]2[CH2:26][CH2:27][C@@H:23]([OH:22])[CH2:24]2)[CH:11]=1

Participants

4

Reactant 2

HCID 2759337(R)-3-PyrrolidinolHCID 11483278HCID 11483278, compound

Product 1

HCID 69686397HCID 69686397, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound, m.p. 270-274° C., [α]D20 =−34° (c=0.54, methanol) and MS: m/e=346.3 (M+H+), was prepared from 2-chloro-4-(3,4-dihydro-1H-isoquinolin-2yl)-quinoline and (R)-3-hydroxypyrrolidine

Sources & evidence

ORD record
ord-45b4b627886544dcbcaf1a956d254781
Source dataset
uspto-grants-2002_01
Patent number
US06339093B1

Reaction notes

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