Prolinol, (R)- → HCID 70159194, compound

HRID 1250468Notes

Reaction equation

HRID 1250468 reaction equation
Cl[C:2]1[CH:11]=[C:10]([N:12]2[CH2:21][CH2:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH:22]1[CH2:28][CH2:27][CH2:26][C@@H:23]1[CH2:24][OH:25]>CO>[CH2:13]1[C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:20][CH2:21][N:12]1[C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=[C:2]([N:22]2[CH2:28][CH2:27][CH2:26][C@@H:23]2[CH2:24][OH:25])[CH:11]=1

Participants

4

Reactant 2

HCID 2724541Prolinol, (R)-HCID 11483278HCID 11483278, compound

Product 1

HCID 70159194HCID 70159194, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound, m.p. 74-80° C., [α]D20 =30 63.2° (c=0.53, methanol) and MS: m/e=360.3 (M+H+), was prepared from 2-chloro-4-(3,4-dihydro-1H-isoquinolin-2-yl)-quinoline and D-prolinol.

Sources & evidence

ORD record
ord-9bca5a44054243b484b4a7da07e97a62
Source dataset
uspto-grants-2002_01
Patent number
US06339093B1

Reaction notes

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