4-Chloroquinoline → HCID 18326772, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-chloroquinoline (0.245 g, 1.5 mmol) and 5-Chloro-2,3-dihydro-1H-isoindole (0.23 g, 1.5 mmol) was heated at 140-150° C. for 4 hours under Argon then cooled to room temperature. The crude product was recrystallized with methanol to provide 4-(5-Chloro-1,3-dihydro-isoindol-2-yl)-quinoline hydrochloride (0.115 g, 24%) as white solid, m.p. 270-275° C. and MS: m/e=280 (M+).

Provenance & Evidence