Water → 4-Methoxy-6-[3-(trifluoromethyl)phenoxy] picolinic acid

Participants

Reaction Conditions

Reaction Steps

1.0 g (0.0032 mol) of 2-cyano-4-methoxy-6-(3-(trifluoromethyl)phenoxy} pyridine was suspended in about 10 ml of concentrated hydrochloric acid, followed by stirring the obtained suspension at about 100° C. for about 2 hours. After being allowed to stand for cooling, the reaction solution was mixed with water. The reaction solution was distributed in ethyl acetate-water, followed by washing with saturated brine. Further, the product was dried with anhydrous sodium sulfate, concentrated and purified by silica gel column chromatography, thereby obtaining an aimed product.

Provenance & Evidence