Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Boc-L-Valine → 1-{1-(RS)-[4-(3,4-dichlorobenzyl)piperazin-1-ylmethyl]-2-methylpropyl}-3-methoxybenzyl-2-thiourea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Boc-L-Valine | HCID 83693 | — |
| 반응물 | 3-Methoxybenzyl isothiocyanate | HCID 126512 | — |
| 반응물 | n-{1 (s)-[4-(3,4-Dichlorobenzyl)piperazin-1-ylmethyl]-2-methylpropyl}-4-methylbenzamide dihydrochloride salt | HCID 9958340 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1-{1-(RS)-[4-(3,4-dichlorobenzyl)piperazin-1-ylmethyl]-2-methylpropyl}-3-methoxybenzyl-2-thiourea | HCID 86588980 | — |
반응 단계
3-Methoxybenzyl isothiocyanate (22 mg, 0.12 mmol) was added to a solution of 1-(RS)-[4-(3,4-dichlorobenzyl)piperazin-1-ylmethyl]-2-methylpropylamine (40 mg, 0.12 mmol) [prepared as described in Example 1 by substituting L-N-BOC-valine with DL-N-BOC-valine] in methylene chloride (1.5 ml). The reaction mixture was stirred for 2 h and then concentrated. Purification by flash chromatography with 20:1 methylene chloride:methanol as the eluant gave 1-{1-(RS)-[4-(3,4-dichlorobenzyl)piperazin-1-ylmethyl]-2-methylpropyl}-3-methoxybenzyl-2-thiourea (18 mg) as a solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06339087B1 |
| 출처 데이터셋 | uspto-grants-2002_01 |
| ORD ID | ord-4dd00b54e34a4693a58e485d52974d3f |
| 출처 메모 | uspto-grants-2002_01 |