HCID 23503328, compound → HCID 18680423, compound

HRID 1250546Notes

Reaction equation

HRID 1250546 reaction equation
[I-].[Cl:2][C:3]1[CH:4]=[C:5]([CH:36]=[CH:37][C:38]=1[Cl:39])[CH2:6][CH:7]1[CH2:12][CH2:11][N+:10]([CH2:34][CH3:35])([CH2:13][CH:14]([NH:18][C:19]([NH:21][C:22]2[CH:27]=[C:26]([O:28][CH3:29])[C:25]([O:30][CH3:31])=[C:24]([O:32][CH3:33])[CH:23]=2)=[O:20])[CH:15]([CH3:17])[CH3:16])[CH2:9][CH2:8]1>CO>[Cl-:2].[Cl:2][C:3]1[CH:4]=[C:5]([CH:36]=[CH:37][C:38]=1[Cl:39])[CH2:6][CH:7]1[CH2:8][CH2:9][N+:10]([CH2:34][CH3:35])([CH2:13][CH:14]([NH:18][C:19]([NH:21][C:22]2[CH:27]=[C:26]([O:28][CH3:29])[C:25]([O:30][CH3:31])=[C:24]([O:32][CH3:33])[CH:23]=2)=[O:20])[CH:15]([CH3:17])[CH3:16])[CH2:11][CH2:12]1

Participants

3

Reactant 1

HCID 23503328HCID 23503328, compound

Product 1

HCID 18680423HCID 18680423, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 4-(3,4-dichlorobenzyl)-1-ethyl-1-{3-methyl-2-[3-(3,4,5-trimethoxyphenyl)ureido]butyl}piperidinium iodide (0.2 g) in methanol (5 ml) was slowly passed through a column of Dowex 1x8-50 ion exchange resin (3 g). The eluted product was concentrated in vacuo to give 4-(3,4-dichlorobenzyl)-1-ethyl-1-{3-methyl-2-[3-(3,4,5-trimethoxyphenyl)ureido]butyl}piperidinium chloride.

Workup

  1. concentrationThe eluted product was concentrated in vacuo

Sources & evidence

ORD record
ord-0aabf01931094799bb03bba340ab97e8
Source dataset
uspto-grants-2002_01
Patent number
US06339087B1

Reaction notes

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